The application of epigenetics in CAR-T therapy
DOI:
https://doi.org/10.56028/aetr.3.1.604Keywords:
CAR-T treatment, epigenetics, cancer immunotherapy, DNA methylation, T cellsAbstract
This article reviews epigenetics (including DNA methylation, histone modification, chromatin remodeling, and non-coding RNA regulation), epigenetic phenomena in T cells, and the progress of research on CAR-T therapies modified from epigenetic regulation, with the aim of providing new insights for CAR-T to improve the safety and efficacy of clinical translation.
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Published
2023-02-01