Widely Targeted Metabolomics Analysis of the Main Bioactive Ingredients in Serissa japonica (Thunb.) Thunb.

Abstract

Objective: To study the metabolite composition from Serissa japonica, explore the substances that play a role in this medicine, and lay the foundation for subsequent pharmacological research. Methods: The different metabolites in Serissa japonica (Thunb.) Thunb. were detected by UPLC-MS/MS technology. Results: The findings indicated that a total 719 differential metabolites in Serissa japonica (Thunb.) Thunb., which are divided into 12 categories, including amino acids and derivatives, phenolic acids, nucleotides and derivatives, flavonoids, quinones, lignans and coumarins, tannins, alkaloids, terpenes, organic acids, lipids, and others. The dominant metabolites are flavonoids, phenolic acids, and lipid compounds. Modern pharmacological research has found that Serissa japonica contains glycosides, tannins, phytosterols, a small number of alkaloids, sugars, and fatty acids, which are the main direction of pharmacological research. Conclusion: The composition of the substances was tested by metabolomics in Serissa japonica (Thunb.) Thunb. for the first time, which can lay the foundation for the study of the material basis for the effectiveness of traditional Chinese medicine formulas and subsequent pharmacological studies, and maximize the role of ethnic medicine.