The Synergistic Effect of Panax Notoginseng Saponins and Nicotinamide Mononucleotides on Anticoagulant

Abstract

Panax notoginseng is a traditional Chinese herbal medicine with rich medicinal value and health care efficacy. Its main active ingredient, panax notoginseng saponins, has pharmacological effects on improving blood circulation and inhibiting platelet aggregation. Nicotinamide mononucleotide has the effect of reducing collagen deposition in blood vessels and reducing vascular obstruction. Method: Compare the thrombolytic efficiency of panax notoginseng saponins and nicotinamide mononucleotide alone and in combination, as well as their effect on prolonging coagulation time, using in vitro anticoagulant experiments and in vitro thrombolysis experiments, to explore the efficacy of panax notoginseng saponins and nicotinamide mononucleotide in combination. The results showed that when combined with a compound drug concentration ratio of 3:1 (PNS: NMN), the coagulation time was 1.2 times that of the PNS liposome single dose group and 1.7 times that of the NMN single dose group. And the optimal dosage for combination therapy is only 50% of the single dose. Conclusion: The combination of PNS and NMN has significant synergistic advantages and saves the dosage, which provides a new drug combination for the development of safe and low-toxic anticoagulant and thrombolytic drugs. It provides a reliable and detailed theoretical basis for the combination of panax notoginseng saponins and nicotinamide mononucleotide.