Mining and biosynthesis strategies of sea cucumber antimicrobial peptides

Abstract

With the abuse of antibiotics, more and more drug-resistant strains have emerged clinically Antimicrobial peptides kill bacteria by inhibiting the synthesis of nucleic acid and protein in cell membrane and regulating cellular immune response. Because of its bactericidal mechanism, antimicrobial peptides can kill many gram-negative bacteria and gram-positive bacteria and are not easy to develop drug resistance, they are good candidates for a new generation of antibiotics to treat multidrug-resistant bacteria Sea cucumber is one of the excellent sources of antimicrobial peptides, but there are few studies on antimicrobial peptides based on sea cucumber at present With the deciphering of genomic proteomic information of sea cucumber and the publication of antimicrobial peptides of sea cucumber, it has attracted wide attention, which provides a new way for rapid acquisition of antimicrobial peptides of sea cucumber In this paper, the characteristics and mechanism of antimicrobial peptides from sea cucumber were summarized, and the mining and preparation strategies of antimicrobial peptides from sea cucumber were summarized.