The effect of gut microbiota on patients with irritable bowel syndrome and depression comorbidity

Abstract

Irritable bowel syndrome (IBS) common conditions that plague many people and can be related to an imbalance in the gut microbiota. In addition, IBS may be complicated by depression, but the impact of gut microbiota on people with IBS and depression has not been determined. This study investigated the effect of gut microbiota on complications of IBS and depression via the ‘gut-brain’ axis. We performed metagenome sequencing for the stool samples collected from healthy controls and from patients with IBS, depression, or the comorbidity of IBS and depression (I&D). Next, we conducted a metagenomic analysis to compare the gut microbiota between different sample groups. We found that Bacteroidales and Clostridiales, including Lachnospiracea_incertae_sedis, Blautia, Faecalibacterium, Coprococcus, Ruminococcus, Paraprevotella, and Gemiger, are major gut microbiota in IBS and depression. This study provides a theoretical basis for the prevention, diet, or other treatment of IBS and depression complications.