Targeting the Warburg Effect: Strategies for Cancer Detection and Therapeutic Interventions

Abstract

 In 1920, Otto Warburg found that the process, of glycolysis, was active in liver cancer cells even under enough oxygen levels, namely cancers derived energy mainly from glycolysis. He considered it as aerobic glycolysis, due to the mitochondria dysfunction in cancers. However, in this review article, I will briefly list the hallmarks of cancers and depict some alterations in Warburg Effect from modern studies. Also, several benefits to cancers by the Warburg Effect will be added, with the latest noninvasive detection techniques and relative therapeutic targets.