Intravenous lipid emulsion for the treatment of acute lipid-soluble anesthetic drug toxicity in pediatric patients

Abstract

Clinical studies on the use of lipid emulsions for the treatment of lipid-soluble anesthetic drug intoxication in children are relatively absent. Since children are not shrinking versions of adults, the therapeutic efficacy of lipid emulsions for the treatment of lipid-soluble anesthetic drug intoxication in pediatric patients is uncertain. This paper investigates the therapeutic efficacy and therapeutic mechanism of intravenous lipid emulsion for reversing acute narcotic drug intoxication in pediatric patients based on clinical data from west China Hospital of Sichuan University. The clinical data of 106 pediatric patients with acute lipid-soluble drug intoxication admitted to an inpatient center in the past 3 years were retrospectively analyzed and randomly divided into an observation group and a control group. The cardiac function indexes and blood gas indexes of patients in both groups were compared before and after treatment. After treatment, the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD) values and plasma B-type natriuretic peptide (BNP) in the observation group were lower than control group, and the left heart ejection fraction (LVEF) was higher than those in the control group, with statistically significant differences (P<0.05). The arterial oxygen saturation (), partial pressure of oxygen () and acid-base (pH) values were higher in the observation group than in the control group, and the partial pressure of carbon dioxide () values were lower than in the control group. And these differences were statistically significant (P<0.05). Therefore, intravenous lipid emulsion has a positive effect in reversing acute fat-soluble anesthetic drug intoxication in pediatric patients, and is effective in promoting recovery of cardiac function, reversing respiratory failure, and improving blood gas indexes. The results of the study demonstrated the effectiveness of intravenous lipid emulsion in reversing pediatric lipid-soluble anesthetic drug intoxication and enrich the clinical research on this issue.